منابع مشابه
Bulbospinal serotonin pressor pathways and hypotensive action of methyldopa in the rat.
The administration of methyldopa (200 mg/kg i.p.) induced a green fluorescence typical of catecholamine fluorescence, in regions of the brain stem which coincided with all the major serotonin cell groups, including the B1, B2, and B3 cell groups in the medulla. Prior administration of 5,7-dihydroxytryptamine (5,7-DHT), a neurotoxin relatively specific for serotonin neurons, prevented the appear...
متن کاملHypotensive action and side effects of clonidine-chlorthalidone and methyldopa-chlorthalidone in treatment of hypertension.
In an open, randomized, cross-over study the hypotensive action and side effects of clonidine-chlorthalidone and methyldopa-chlorthalidone combinations were compared. The diastolic morning blood pressure could be reduced to 95 mm. Hg or below in significantly more patients with clonidine than with methyldopa. Side effects, however, were more commonly encountered during the clonidine than during...
متن کاملDIETARY SALT REDUCTION POTENTIATES THE ACTION OF HYPOTENSIVE DRUGS
Hypertension is a common health problem. Hypotensive drugs and low salt diet are used in its treatment. This study was designed to compare the effectiveness of a low-salt diet and drug therapy in the treatment of arterial hypertension. A total of 256 randomly selected patients with essential hypertension consulting the Non-contagious Diseases Clinic in Shahreza, Isfahan, Iran, were included...
متن کاملHypotensive Action of Reserpine
The effects of large doses of reserpine have been compared in hypertensive and norrmotensive patients. The falls of blood pressure are larger in the hvpertensives than in the normotensives. In normotensive animals small falls of blood pressure occur. Evidence is presented which suggests that the fall of blood pressure in animals is in part mediated through the sympathetic nervous system. There ...
متن کاملStudies on the Metabolism and Mechanism of Action of Methyldopa.
THE decarboxylase-inhibiting, sedative, and antihypertensive properties of amethyl-3,4-dihydroxy-DI,-phenylalanine (DL-amethyl-dopa) in man were first reported from this department in 1960.1 It was shown subsequently that these three properties of the compound reside solely in the L isomer (methyldopa, Aldomet) .2, 3 Numerous favorable reports on the use of methyldopa in the treatment of hypert...
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ژورنال
عنوان ژورنال: BMJ
سال: 1963
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.5324.146